Pregnenolone Complex is a custom formula that provides pregnenolone and the active precursor niacinamide for ultimate delivery of pregnenolone and aid in the protection of the mitochondrial. Pregnenolone is the key precursor pro-hormone involved in maintaining sufficient steroid hormone levels in the body. It is the precursor (building block) for other hormones in the body including cortisol, DHEA, estrogen, progesterone, testosterone and aldosterone.
Without pregnenolone there can be no human steroid hormone production.
Pregnenolone is known to modulate at least two key nerve receptors systems in the brain: NMDA receptors and GABA receptors. NMDA receptors are involved in learning, memory, and alertness. GABA receptors are involved in mood stability, relaxation, sex drive and sleep.
Niacinamide or otherwise known as Vitamin B3 works with vitamin B1, riboflavin (Vitamin B2), pyridoxine (vitamin B6), pantothenic acid, and biotin to break down and convert the carbohydrates, fats, and proteins in food into energy to help support the mitochondria. The involvement of niacin, an essential B vitamin, in cellular energy production makes it important for healthy cardiovascular function, nervous system function and immune function.
Methyl Folate Complex is designed to be used in conjunction with our Methylation Support Dissolves or Methylation Support Topical Cream that provides the activating co-factors to deliver the additional tetrahydrofolate to support issues associated with methylation deficiencies.. Most often poor methylators will need additional methyl folate.
The addition of Niacinamide helps support the mitochondria and supports as a cofactor for the delivery of the other ingredients in Methyl Folate Plus.
The typical indications for this product include but are not limited to:
* Presence of Folate Receptor Autoantibodies
*Homozygous (2 copies) MTHFR polymorphism
*Development (ages 8-20)
*Slow recovery from major neurological injuries
*Moderate to severe autism spectrum issues
*Poor recovery from traumatic injury
Palmitoylethanolamide (PEA) is a bio-identical fatty acid amide that Is normally synthesized by healthy tissue In the human body in response to inflammation. PEA is made by various plants and animals and is present throughout the animal kingdom. PEA can be found in many different tissuesincluding glia, neurons, retina, white blood cells, mast cells and adipocytes. Supplementing with PEA has been sclentlffcally shown to naturally assist in the reduction of inflammation and to have neuro-protective and possibly pain control effects. This natural anti-inflammatory supports the nervous system and abnormal immune responses.*
Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with:
How does it work?Palmitoylethanolamide is thought to act primarily on the Peroxisome Proliferator Activated Receptor Alpha (PPAR-α), a receptor in the cell nucleus. It also has affinity for the cannabinoid-like G-coupled receptors GPR55 and GPR119, although it has no affinity for the classical cannabinoid receptors CB1 and CB2. This is why it is sometimes referred to as a non-psychoactive “indirect endocannabinoid.”
It does not block pain signals the way opioids and other analgestics do. Instead it works upstream by supporting the healthy function of glial cells and mast cells.*
Palmitoylethanolamid (PEA) is a bio-identical fatty acid amide that is normally synthesized by healthy tissue in the human body in response to inflammation. PEA is made by various plants and animals and is present throughout the animal kingdom. PEA can be found in many different tissues including glia, neurons, retina, white blood cells, mast cells and adipocytes.
Supplementing with time released PEA has been scientlfcally shown to naturally assist in the reduction of inflammation and to have neuro-protective and possibly pain control effects. This natural anti-inflammatory supports the nervous system and abnormal immune responses.*
Mast cells are a type of immune system cell that responds to chemical signals from tissue injury. When mast cells “degranulate,” they release a payload of inflammatory cytokines, NGF, histamines, and other molecules in the surrounding tissue. These chemicals attract white blood cells and activate their immune response against pathogens. Mast cells also activate nociceptors (pain receptors) with the chemicals they secrete. Overactive mast cell activation induces an increase in the density and sensitivity of pain receptors and can play a part in a variety of chronic pain issues.
How does it work?It was discovered that mammals have a specific receptor cell known as the endocannabinoid system, which is closely interconnected with the nervous and immune system. CBD has been shown to boost every function of our cannabinoid receptors to help soothe and relax us. PEA has an affinity for the cannabinoid-like G-coupled receptors, although it has no affinity for the classical cannabinoid receptors CB1 and CB2. This is why it is sometimes referred to as a non-psychoactive “indirect endocannabinoid.”
9 ingredients to assist in the support and function of the mitochondria.
Pyrroloquinoline Quinone(PQQ) and NADH(B3) are two major ingredients which form this powerful supplement. With the combination of these 9 ingredients, selected by our advising physicians, ensures that these key ingredients stimulate proper mitochondrial function and guard against mitochondrial degeneration.